نشر تدريسيان في قسم علوم الحياة أ.م.د. مصطفى علي عبدالرحمن و م.د. حارث احمد مصطفى مقالة علمية في مجلة عالمية ( Science archive )
Fertility is remarkably declines with age for females in both spontaneous conceptions and pregnancies following assisted reproductive methods (Templeton et al., 1996). The period of optimal fertility lasts until the age of about 30 yr and decreases gradually thereafter. The decrease in fertility is probably because of the decreasing number of primordial follicles after birth; by the age of 37-38 yr, the follicle pool is significantly decreased, (Faddy et al., 1992) as is the quality and quantity of oocytes (Novot et al., 1991). Anti-Mullerian hormone (AMH), or Mullerian Inhibiting Substance, is also known as one of the most important markers of ovarian reserve (Van Rooij et al., 2002). In the ovary, AMH inhibits initial primordial follicles recruitment and decreases the sensitivity of preantral and small antral follicles to follicle-stimulating hormone (FSH) (Durlinger et al., 2002), hence suggesting its role in intrafollicular and interfollicular coordination of follicle development (Salmon et al., 2004). It has been found that human antral follicles measuring < 6 mm express the greatest amount of AMH, and that levels decline as antral follicles increase in size. It has become clear that AMH also plays an important role in ovarian function, especially follicle development and follicle selection (Al-Kanaani et al., 2020). Furthermore, AMH is elevated in females with polycystic ovary syndrome (PCOS) compared with control, leading to the hypothesis that exaggerated AMH could be involved in follicular arrest seen in polycystic ovaries (Pigny et al., 2006). AMH is strongly correlated to antral follicle count (AFC), and both predictors have a linear relationship with age (Mustafa et al., 2019). Confirming the decline of ovarian reserve with age. Many researchers have found that basal AMH levels accurately reflect the total developing follicular cohort and ovarian response to gonadotrophin in ART cycles (Hazont et al., 2004). As yet, AMH testing, like other predictive markers, doesn’t appear to predict accurately the probability of pregnancy after IVF treatment (Broer et al., 2008).
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